2011 Fiscal Year Final Research Report
Chronic morphine treatment and angiogenesis
| Project/Area Number |
22791423
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shinshu University |
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Principal Investigator |
ISHIDA Takashi 信州大学, 医学部・附属病院, 特任研究員 (60531952)
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| Project Period (FY) |
2010 – 2011
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| Keywords | オピオイド / 腫瘍増大 / 血管新生 / CGRP / アドレノメデュリン |
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| Research Abstract |
Chronic treatment of morphine at low doses(0. 1-3mg/kg/day) attenuated the growth of Lewis lung carcinoma(LLC) in C57BL/6 mice. However, higher dose(10mg/kg/day) of morphine does not affect LLC growth. These results suggest that effects of chronic morphine treatment on growth of LLC may be biphasic alteration.
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