2011 Fiscal Year Final Research Report
Effects of microparticles on monocyte-derived procoagulant activity provoked via SP : NK1R pathway
| Project/Area Number |
22791454
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 周術期管理学 / マイクロパーティクル / 単球 / ニューロキニン1受容体 / サブスタンスP / 血液凝固 / 組織因子 |
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| Research Abstract |
Substance-P(SP) enhances whole blood coagulation through neurokinin-1 receptors(NK1R) in leukocytes while the precise mechanisms of this phenomenon remains to be established. Thus the effects of microparticles associated with tissue factor on monocyte-derived procoagulant activity provoked via SP : NK1R pathway were evaluated. CC chemokine ligand 5(CCL5) increased microparticles released from monocytes. SP enhanced CCL5-dependent release of microparticles from these cells. Forced expression of the full-length NK1R that is not constitutively expressed in monocytes also enhanced the release of microparticles from these cells.
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