2011 Fiscal Year Final Research Report
The study of the new molecular cancer treatment targeting for apoptosis inhibitor survivin.
| Project/Area Number |
22791466
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Gunma University |
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Principal Investigator |
KOIKE Hidekazu 群馬大学, 大学院・医学系研究科, 助教 (90420091)
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| Project Period (FY) |
2010 – 2011
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| Keywords | サバイビン / 前立腺癌 / 腎癌 |
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| Research Abstract |
We suggested that survivin have significant associations with prostate cancer cell proliferation, plays an essential role in simvastatin induced cell growth inhibition, and plays an essential role in active D3 induced cell growth inhibition in prostate cancer. The elimination of Survivin would be also a potential candidate for a novel approach to treat prostate cancer.
In renal cell cancer, simvastatin has anticancer effect being associated with IGF-1r. Survivin is associated with simvastatin resistance of renal cancer cells.
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