2011 Fiscal Year Final Research Report
Effects of functional domains of osteopontin on renal crystal formation
Project/Area Number |
22791479
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Urology
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Research Institution | Nagoya City University |
Principal Investigator |
HAMAMOTO Shuzo 名古屋市立大学, 大学院・医学研究科, 臨床研究医 (80551267)
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Project Period (FY) |
2010 – 2011
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Keywords | 腎結石 / オステオポンチン抗体 / 霊長類 |
Research Abstract |
The results of this stusdy indicated the possibility that two kinds of functional domains of osteopontin including calcium binding domain and RGD sequence contribute to the mechanism by which OPN stimulates crystal formation.
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[Journal Article] Role of osteopontin in early phase of renal crystal formation2012
Author(s)
Hirose M, Tozawa K, Okada A, Hamamoto S, Higashibata Y, Gao B, Hayashi Y, Shimizu H, Kubota Y, Yasui T, Kohri K
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Journal Title
Urol Res
Volume: 40
Pages: 121-9
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[Journal Article] Mitochondrial permeability transition pore opening ind uces the initial process of renal calcium crystallization2012
Author(s)
Niimi K, Yasui T, Hirose M, Hamamoto S, Itoh Y, Okada A, Kubota Y, Kojima Y, Tozawa K, Sasaki S, Hayashi Y, Kohri K
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Journal Title
Free Radic Biol Med
Volume: 52
Pages: 1207-17
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[Journal Article] Crucial role of the cryptic epitope SLAYGLR within osteopontin in renal crystal formation of mice2011
Author(s)
Hamamoto S, Yasui T, Okada A, Hirose M, Matsui Y, Kon S, Sakai F, Kojima Y, Hayashi Y, Tozawa K, Uede T, Kohri K
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Journal Title
J Bone Miner Res
Volume: 26
Pages: 2967-77
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[Journal Article] The role of long-term loading of ch olesterol in renal crystal formation2011
Author(s)
Itoh Y, Yoshimura M, Niimi K, Usami M, Hamamoto S, Kobayashi T, Hirose M, Okada A, Yasui T, Tozawa K, Kohri K
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Journal Title
Arch Ital Urol Androl
Volume: 83
Pages: 23-5
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[Journal Article] Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice : Detection by association analysis of stone-related gene expression and microstructural observation2010
Author(s)
Okada A, Yasui T, Fujii Y, Niimi K, Hamamoto S, Hirose M, Kojima Y, Itoh Y, Tozawa K, Hayashi Y, Kohri K
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Journal Title
J Bone Miner Res
Volume: 25
Pages: 2701-11
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[Presentation] Regional variations and characteristics of urolithiasis in Japan determined from a national survey2011
Author(s)
Yasui Takahiro, Okada Atsushi, Taguchi Kazumi, Fujii Yasuhiro, Niimi Kazuhiro, Usami Masayuki, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
Organizer
26th Annual EAU(European Association of Urology) Congress
Place of Presentation
Vienna(Austria)
Year and Date
20110318-22
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[Presentation] Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice2011
Author(s)
Okada Atsushi, Hamamoto Shuzo, Ichikawa Jun, Nakaoka Kazunori, Hirose Yasuhiko, Taguchi Kazumi, Fujii Yasuhiro, Niimi Kazuhiro, Usami Masayuki, Kobayashi Takahiro, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
Organizer
26th Annual EAU(European Association of Urology) Congress
Place of Presentation
Vienna(Austria)
Year and Date
20110318-22
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[Presentation] Hypothetical new aspects of human kidney stone formation ; comparison of clinical and pathological findings of stone-forming and non-stone-forming kidneys2011
Author(s)
Okada Atsushi, Nakaoka Kazunori, Ichikawa Jun, Hirose Yasuhiko, Taguchi Kazumi, Niimi Kazuhiro, Fujii Yasuhiro, Usami Masayuki, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
Organizer
26th Annual EAU(European Association of Urology) Congress
Place of Presentation
Vienna(Austria)
Year and Date
20110318-22
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[Presentation] Osteopontin has a crucial role in ultrastructural conversion of calcium oxalate crystals into matrix-involving kidney stones2011
Author(s)
Okada Atsushi, Hamamoto Shuzo, Ichikawa Jun, Nakaoka Kazunori, Taguchi Kazumi, Hirose Yasuhiko, Fujii Yasuhiro, Niimi Kazuhiro, Usami Masayuki, Kobayashi Takahiro, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
Organizer
26th Annual EAU(European Association of Urology) Congress
Place of Presentation
Vienna(Austria)
Year and Date
20110318-22
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[Presentation] Renal macrophages play a major role in defence against renal stone formation by elimination of crystals2011
Author(s)
Taguchi Kazumi, Okada Atsushi, Fujii Yasuhiro, Niimi Kazuhiro, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
Organizer
26th Annual EAU(European Association of Urology) Congress
Place of Presentation
Vienna(Austria)
Year and Date
20110318-22
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[Presentation] Pioglitazone, peroxisome proliferator-activated receptor gamma activator, possible inhibition of renal stone formation in rats2011
Author(s)
Taguchi Kazumi, Okada Atsushi, Fujii Yasuhiro, Niimi Kazuhiro, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
Organizer
26th Annual EAU(European Association of Urology) Congress
Place of Presentation
Vienna(Austria)
Year and Date
20110318-22
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[Presentation] Osteopontin has a crucial role in ultrastructural conversion of calcium oxalate crystals into matrix-involving kidney stones2010
Author(s)
Okada Atsushi, Taguchi Kazumi, Nakaoka Kazunori, Hirose Yasuhiko, Fujii Yasuhiro, Niimi Kazuhiro, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
Organizer
FASEB Summer Research Conferences ; Osteopontin Biology
Place of Presentation
Steamboat Springs, Colorado, U. S. A.
Year and Date
20100801-06
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[Presentation] Effects of impaired functional domains of osteopontin on renal crystal formation2010
Author(s)
Hamamoto Shuzo, Yasui Takahiro, Okada Atsushi, Hirose Masahiro, Kobayashi Takahiro, Niimi Kazuhiro, Fujii Yasuhiro, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
Organizer
FASEB Summer Research Conferences ; Osteopontin Biology
Place of Presentation
Steamboat Springs, Colorado, U. S. A.
Year and Date
20100801-06
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[Presentation] The role of long-term loading of cholesterol in renal crystal formation2010
Author(s)
Itoh Yasunori, Niimi Kazuhiro, Usami Masayuki, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, Okada Atsusi, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
Organizer
AUA 2010 Annual Meeting
Place of Presentation
San Francisco, USA
Year and Date
20100529-0603
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[Presentation] Development of a new method for measuring serum oxalate using a tris(2, 2'-bipyridyl) ruthenium(II) c hemiluminescence analysis system and importance in urolithiasis patients2010
Author(s)
Yasui Takahiro, Okada Atsushi, Kobayashi Takahiro, Hirose Masahito, Nakaoka Kazunori, Taguchi Kazumi, Fujii Yasuhiro, Niimi Kazuhiro, Hirose Yasuhiko, Usami Masayuki, Hamamoto Shuzo, Itoh Yasunori, Yamada Yasuyuki, Tozawa Keiichi, Kohri Kenjiro
Organizer
AUA 2010 Annual Meeting
Place of Presentation
San Francisco, USA
Year and Date
20100529-0603
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