2012 Fiscal Year Final Research Report
The mechanism of urolithiasis formation and the analysis of adipocytokine under metabolic syndrome
| Project/Area Number |
22791481
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
FUJII Yasuhiro 名古屋市立大学, 大学院・医学研究科, 研究員 (30566229)
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| Project Period (FY) |
2010 – 2012
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| Keywords | メタボリックシンドローム / 炎症 / オステオポンチン / アディポネクチン / 酸化ストレス / 尿路結石 |
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| Research Abstract |
In this study, Kidney crystal formation in the MetS environment increased OPN and MCP-1 expression, and decreased SOD expression in renal tissue. Collectively, APN is possible to prevent kidney stone by regulating inflammation and oxidative stress at the biomolecular level. Next, the renal tubular epithelial cells and adipocytes showed characteristic expression patterns of kidney stone-related genes in the coculture. These phenomena might be due to MetS environment-induced paracrine system between renal tubular epithelial cells and adipocytes, and suggests that MetS environment may lead to kidney stone formation.
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[Journal Article] Effect of Adiponectin on Kidney Crystal Formation in Metabolic Syndrome Model Mice via Inhibition of Inflammation and Apoptosis.2013
Author(s)
Fujii Y, Okada A, Yasui T, Niimi K, Hamamoto S, Hirose M, Kubota Y, Tozawa K, Hayashi Y, Kohri K.
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Journal Title
PLoS One
Volume: Vol.8, No.4
Pages: e61343
DOI
Peer Reviewed
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[Presentation] The role of long-term loading of cholesterol in renal crystal formation2012
Author(s)
Fujii Yasuhiro, Okada Atsushi, Taguchi Kazumi, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Kojima Yoshiyuki, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
Organizer
American Urological Association Annual Meeting 2012
Place of Presentation
Atlanta(USA)
Year and Date
20120519-24
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[Presentation] Adiponectin is a possible inhibitor for metabolic syndrome induced kidney stone formation using ob/ob mouse.2011
Author(s)
Fujii Yasuhiro, Okada Atsushi, Ichikawa Jun, Niimi Kazuhiro, Kobayashi Takahiro, Hamamoto Shuzo,Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
Organizer
1st Meeting of the EAU Section of Urolithiasis (EULIS)
Place of Presentation
London(United Kingdom)
Year and Date
20110907-10
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