2011 Fiscal Year Final Research Report
Oxygen nano-bubble water reduces renal calcium oxalate deposits and renal tubular cell injury in a hyperoxaluric rat model
| Project/Area Number |
22791483
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
HIROSE Yasuhiko 名古屋市立大学, 大学院・医学研究科, 研究員 (60381894)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 高シュウ酸尿症 / 酸素ナノバブル水 / 腎結石 / 炎症 |
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| Research Abstract |
Kidney stone resembles arteriosclerosis in the mechanism, calcification composition and epidemiology. Water including oxygen nano-bubbles(nanometer-sized bubbles generated from oxygen microbubbles ; ONB water) has anti-inflammatory effects. Based on these anti-inflammatory effects, ONB water has been reported as a useful therapy for atherosclerosis. Therefore, we investigated the inhibitory effects of ONB water on kidney stone formation using a hyperoxaluric rat model. Our results suggest that ONB water reduces crystal retention in hyperoxaluric rats due to decreased renal tubular cell injury and resulting expression of crystal binding molecules(osteopontin : OPN and hyaluronic acid : HA).
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