2011 Fiscal Year Final Research Report
The new treatment strategy of gene immunotherapy ; survivin gene induce cyototoxic lymphocyte and modify the function of dendritic cells
| Project/Area Number |
22791492
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
FUJII Reona 和歌山県立医科大学, 医学部, 博士研究員 (30326368)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 腫瘍学 |
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| Research Abstract |
Survivin is a member of the inhibitor of apoptosis protein(IAP) family. The present study showed that survivin-specific cytotoxic T lymphocytes(CTLs) can be induced by dendritic cells : DCs transduced with the survivin gene by way of an adenoviral vector, and such CTLs showed cytotoxic activities against human urologic malignancies. Survivin is overexpressed in most cancer cells and chemotherapy-resistant cancer cells but is undetectable in normal tissues. This data suggested survivin is useful for chemotherapy-resistant cancer cells.
Survivin inhibits apoptosis and controls cell division. We showed the cell viability of DCs transduced with the survivin gene is longer than that of "normal" DCs. DCs transduced with the survivin gene can induce survivin-specific CTLs. The cytotoxic activity against bladder cancer cells(T-24) act long period.
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