Biological significance of expression of aryl hydrocarbon receptor in bladder cancer

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791494
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: ISHIDA Masaru 慶應義塾大学, 医学部, 助教 (80383876)
• Project Period (FY): 2010 – 2011
• Keywords: 腫瘍学

Research Abstract

In clinicopathological study, the expression of aryl hydrocarbon receptor(AhR) significantly associated with lymphovascular invasion which is prognostic factor of urothelial cancer. The regulation of the expression of AhR correlated with the expression of matrix metalloproteinase(MMP) in in vitro study. Furthermore, the invasion activity of bladder cancer cell was affected by the expression status of AhR.

Research Products

• [Journal Article] Expression of Snail in upper urinary tract urothelial carcinoma : Prognostic significance and implications for tumor invasion (2010)
  • Author(s): Kosaka T, Mikami S, Miyajima A, Shirotake S, Ishida M, Okada Y, Oya M
  • Journal Title: Clinical Cancer Research Volume: 16(23) Pages: 5814-5823
  • Peer Reviewed
• [Presentation] Activation of the aryl hydrocarbon receptor pathway enhances cancer cell invasion by up-regulating the MMP expression in urothelial cancer (2011)
  • Author(s): Ishida M, Mikami S, Kikuchi E, Kosaka T, Miyajima A, Mukai M, Okada Y, Oya M
  • Organizer: The 106th annual meeting of American Urological Association
  • Place of Presentation: アメリカワシントンDC
  • Year and Date: 2011-05-16
• [Presentation] Metastin, the final peptide of KISS-1 gene, prevents lung metastases of murine bladder cancer (2011)
  • Author(s): Takeda T, Kikuchi E, Suzuki E, Ito Y, Ishida M, Matsumoto K, Miyajima A, Mikami S, Oya M
  • Organizer: The 106th annual meeting of American Urological Association
  • Place of Presentation: アメリカワシントンDC
  • Year and Date: 2011-05-16
• [Presentation] Activation of the AhR pathway enhances cancer cell invasion by up-regulating the MMP expression in urothelial cancer (2010)
  • Author(s): Ishida M, Mikami S, Kikuchi E, Kosaka T, Miyajima A, Nakagawa K, Mukai M, Okada Y, Oya M
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Remarks]
  • URL: http://www.keio-urology.jp/achievement/index.html