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2013 Fiscal Year Final Research Report

A long ncRNA DD3 promotes cell growth by suppressing pro-apoptotic BMCC1 expression in prostate cancer.

Research Project

  • PDF
Project/Area Number 22791507
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionChiba Cancer Center (Research Institute)

Principal Investigator

TATSUMI Yasutoshi  千葉県がんセンター(研究所), 研究所 がんゲノム研究室, 研究員 (00450578)

Project Period (FY) 2010-04-01 – 2014-03-31
Keywords前立腺がん / BMCC1蛋白質 / アポトーシス促進因子 / siRNA / ノンコーディングRNA
Research Abstract

The Long non-coding RNA, DD3, gene was mapped at the intron 6 within BMCC1 gene in an opposite way. In prostate cancer cell lines, there occurred inverse regulation in BMCC1 and DD3 expression. These suggested that DD3 targets BMCC1 for its expression to be decreased in prostate cancer cells. In contrast to higher expression of DD3 in prostate cancer tissues, lower expression of BMCC1 in primary prostate cancers in compared with corresponding normal tissues were detected by immunohistochemistry using anti-BMCC1 antibody. In addition, we found that BMCC1 is a key facilitator of mitochondrial apoptosis and DNA damage-induced drug sensitivity through AKT attenuation and associates with Bcl-2. Because DD3 knockdown facilitated the reduction of cell viability and promotion of Cisplatin sensitivity through pro-apoptotic BMCC1 accumulation, we proposed that combination therapy with DD3 siRNA and Cisplatin would be of potential value for treating DD3 positive aggressive prostate cancer.

  • Research Products

    (17 results)

All 2013 2012 2011 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (15 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Novel adaptor protein Shf interacts with ALK receptor and negatively regulates its downstream signals in neuroblastoma2013

    • Author(s)
      Daisuke Takagi, Yasutoshi Tatsumi, Tomoki Yokochi, Atsushi Takatori, Miki Ohira, Takehiko Kamijo, Satoshi Kondo, Yoshitaka Fujii, and Akira Nakagawara
    • Journal Title

      Cancer Science

      Volume: 104 Pages: 563-572

    • DOI

      10.1111/cas.12115

    • Peer Reviewed
  • [Presentation] TAp63 trans-activates the expression of BMCC1 and promotes apoptosis in neuroblastoma2013

    • Author(s)
      Mohammad Sazzadul Islam, Yasutoshi Tatsumi, Ryo Takano, Yusuke Suenaga, Yohko Nakamura, Akira Nakagawara
    • Organizer
      6th p63/p73 International Workshop
    • Place of Presentation
      木更津
    • Year and Date
      20130916-18
  • [Presentation] The scaffold protein BMCC1 promotes apoptosis via the mitochondrial pathway and is downregulated in cancers2013

    • Author(s)
      Yasutoshi Tatsumi, Mohammad S. Islam, Akira Nakagawara
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-03
  • [Presentation] E2F1-dependent transcriptional upregulation of proapoptotic BMCC1 in favorable neuroblastoma2013

    • Author(s)
      Mohammad S. Islam, Yasutoshi Tatsumi, Jesmin Akter, Akira Nakagawara
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-03
  • [Presentation] E2F1-dependent Transcriptional Regulation of Pro-apoptotic BMCC1 during DNA Damage-induced Apoptosis2012

    • Author(s)
      Mohammad Sazzadul Islam, Yasutoshi Tatsumi, Ryo Takano, Jesmin Akter, Akira Nakagawara
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
  • [Presentation] BMCC1, a novel pro-apoptotic protein down-regulated in cancers, is induced by DNA damage and promotes mitochondrial apoptosis through anti-apoptotic Bcl-2 proteins2012

    • Author(s)
      巽 康年, 高野 良, モハマド サジャドウル イスラム, 中川原章
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
  • [Presentation] 第 54 回日本小児血液2012

    • Author(s)
      Mohammad Sazzadul Islam, Yasutoshi Tatsumi, Ryo Takano, Jesmin Akter, Yohko Nakamura, Akira Nakagawara
    • Organizer
      がん学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-12-02
  • [Presentation] BMCC1, a novel protein downregulated in cancers, binds to Bcl-2 and promotes apoptosis through caspase-9 activation2012

    • Author(s)
      巽 康年, 高野 良, モハマド サジャドウール イスラム, 中村 洋子, 中川原章
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
  • [Presentation] 前立腺がん細胞においてノンコーディングRNAの DD3 はアポトーシス促進因子BMCC1の発現抑制を介して細胞増殖を促進する2011

    • Author(s)
      巽 康年, 高野 良, 中村 洋子, 植田 健, 中川原章
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-05
  • [Presentation] 予後良好な神経芽腫で高発現する Shf はALKとの結合を介してALK依存的な生存シグナルを抑制する2011

    • Author(s)
      高木 大輔, 巽 康年, 高取 敦志, 大平 美紀, 上條 岳彦, 近藤 知史, 中川原章
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] 予後良好な神経芽腫で高発現する Shf はALKとの結合を介してALK依存的な生存シグナルを抑制する2011

    • Author(s)
      高木 大輔, 巽 康年, 高取 敦志, 大平 美紀, 上條 岳彦, 近藤 知史, 中川原章
    • Organizer
      第20回日本癌病態治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-18
  • [Presentation] SH2 domain containing adaptor protein Shf, a favorable prognostic factor of neuroblastoma, inhibits ALK-induced oncogenic signals in neuroblastoma2010

    • Author(s)
      Yasutoshi Tatsumi, Daisuke Takagi, Atsushi Takatori, MIki Ohira, Takehiko Kamijo, Satoshi Kondo, Akira Nakagawara
    • Organizer
      Advanced in Neuroblastoma Research 2012
    • Place of Presentation
      カナダ・トロント
    • Year and Date
      20100618-21
  • [Presentation] 新規アポトーシス促進因子BMCC1遺伝子座中にコードされるDD3遺伝子の神経芽腫悪性化における意義2010

    • Author(s)
      巽 康年, 横山 智彰, 高野 良, 大平 美紀, 中川原章
    • Organizer
      第26回日本小児がん学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-18
  • [Presentation] 予後良好な神経芽腫で高発現するShfはALKとの結合を介して ALK 依存的な生存シグナルを抑制する2010

    • Author(s)
      高木 大輔, 巽 康年, 高取 敦志, 大平 美紀, 上條 岳彦, 中川原章
    • Organizer
      第26回日本小児がん学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-17
  • [Presentation] 前立腺がんにおいてlarge non-coding RNAのDD3はBMCC1の発現を抑制し細胞の生存を促進する2010

    • Author(s)
      巽 康年, 横山 智彰, 高野 良, 大平 美紀, 中村 洋子, 植田 健, 中川原章
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
  • [Presentation] DD3, a large non-coding RNA against the pro-apoptotic BMCC1 gene, is a candidate target for treating neuroblastoma2010

    • Author(s)
      巽 康年, 横山 智彰, ウーミャット リン, 高野 良, 高木 大輔, 大平 美紀, 中川原章
    • Organizer
      Advanced in Neuroblastoma Research 2010
    • Place of Presentation
      スウェーデン・ストックホルム
    • Year and Date
      2010-06-22
  • [Patent(Industrial Property Rights)] がんマーカー, および, がんの治療剤2009

    • Inventor(s)
      巽 康年, 中川原 章
    • Industrial Property Rights Holder
      久光製薬株式会社, 千葉県
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特許願2009-267463号
    • Filing Date
      2009-11-25

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Published: 2015-06-25  

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