2013 Fiscal Year Final Research Report
Basic research for new treatment development using microRNA in UPSC
| Project/Area Number |
22791509
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Fumihiko 東北大学, 医学(系)研究科(研究院), 助教 (20400343)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 癌 / エピジェネティクス / miRNA / 子宮体癌 / 漿液性腺癌 |
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| Research Abstract |
Uterine papillary serous carcinoma (UPSC) is a highly aggressive form of endometrial cancer and characterized by a high recurrence rate and a poor prognosis. To date, the standard treatment for UPSC has remained elusive. In the present study, we focused on microRNA (miRNA) that has been recently reported to be abnormal expressed in several cancers and the correlation between miRNA and UPSC. By introducing miRNA whose expression was down-regulated to UPSC cells suppressed cell proliferation. Furthermore, the inhibitory effects may be mediated by the suppression of the oncogenes that were showed as the targets of the miRNA. Taken together, the present study revealed that a novel and important role of miRNA as a tumor suppressor in UPSC and the identification of novel tumor-suppressive miRNA-mediated molecular pathways and targets may provide new insights into UPSC.
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