2011 Fiscal Year Final Research Report
Implication of adipocytokines in implantation and establishment of pregnancy
| Project/Area Number |
22791517
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Teikyo University (2011)
The University of Tokyo (2010) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OSUGA Yutaka 東京大学, 大学院・医学系研究科, 教授 (80260496)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 着床 / 子宮内膜 / アディポサイトカイン / AMP キナーゼ |
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| Research Abstract |
The imbalance of adipocytokines, adipocyte-derived cytokines, has the potential to impair implantation and establishment of pregnancy through abnormality in the control of inflammatory response in the human endometrium. The expression of adiponectin, one of adipocytokines, receptors was increased in the endometrium in the implantation period and the expressions of adiponectin receptors and AMPK phosphorylations were decreased in the endometirium of infertile women i n the implantation period compared with fertile women, suggesting that adiponectin and metformin-induced AMPK phosphorylation may play a facilitatory role in the implantation.
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