Identification of cancer stem cells and establishment of new target therapy in endometrial cancer

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791521
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Kanazawa University
• Principal Investigator: MITSUHIRO Nakamura 金沢大学, 附属病院, 助教 (50377397)
• Project Period (FY): 2010 – 2011
• Keywords: 子宮内膜癌 / 幹細胞 / CD133

Research Abstract

In endometrial cancer cells, CD133-positive cells had properties of self-renewal, tumorigenesis and differentiation, suggesting that CD133 was a potential cancer stem cell(CSC) marker. Immunohistological analysis showed that CD133 expression was significantly associated with overall survival and the independent predictive factor of survival. Furthermore, endometrial CSCs demonstrated high expression of genes associated with multi-drug resistance, invasion and metastasis, indicating that endometrial CSCs are aggressive malignant cancer cells.

Research Products

• [Journal Article] Prognostic impact of CD133 expression as a tumor-initiating cell marker in endometrial cancer (2010)
  • Author(s): Nakamura M, Kyo S, Zhang B, Zhang X, Mizumoto Y, Takakura M, Maida Y, Mori N, Hashimoto M, Ohno S, Inoue M
  • Journal Title: Human Pathology Volume: 41 Pages: 1516-1529
  • DOI: DOI:10.1016/j.humpath.2010.05.006
  • Peer Reviewed
• [Presentation] 婦人科悪性腫瘍における癌幹細胞の同定と癌幹細胞をターゲットとした分子標的治療の基礎的研究 (2011)
  • Author(s): 中村充宏
  • Organizer: 第51回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: ホテルマリターレ創世(福岡県)
  • Year and Date: 2011-11-25
• [Presentation] 子宮内膜癌幹細胞の分化能に関する検討 (2011)
  • Author(s): 中村充宏
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-04
• [Presentation] 子宮内膜癌幹細胞における遺伝子解析の検討 (2011)
  • Author(s): 中村充宏
  • Organizer: 第63回日本産科婦人科学会総会学術講演会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2011-08-30
• [Presentation] Analysis of gene profile and identification of molecular targets in endometrial cancer stem cells (2011)
  • Author(s): Mitsuhiro Nakamura
  • Organizer: American Association for Cancer Research(AACR) 102^<th> Annual Meeting
  • Place of Presentation: Orange country Convention center(USA)
  • Year and Date: 2011-04-05
• [Presentation] 子宮内膜癌における癌幹細胞の同定とそれらをターゲットとした分子標的治療の基礎的研究 (2010)
  • Author(s): 中村充宏
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-24
• [Presentation] 子宮内膜癌細胞における癌幹細胞マーカーの検索 (2010)
  • Author(s): 中村充宏
  • Organizer: 第9回日本婦人科がん分子標的研究会学術集会
  • Place of Presentation: 大津プリンスホテル(滋賀県)
  • Year and Date: 2010-09-10