2011 Fiscal Year Final Research Report
Involvement of mismatch repair abnormalities in the malignant transformation of ovarian endometriosis
| Project/Area Number |
22791524
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shinshu University |
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Principal Investigator |
FUSEYA Chiho 信州大学, 医学部・附属病院, 助教(診療) (50447736)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 子宮内膜症 / 癌化 / ミスマッチ修復 |
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| Research Abstract |
In this study, the mismatch repair(MMR) abnormalities in the carcinogenetic process of endometriosis were analyzed. The immunohistochemical expressions of mismatch repair proteins were step-wisely decreased in normal entopic endometrium, endometriosis, and ovarian carcinoma. Inversely, the step-wisely increasing frequencies of microsatellite instability in normal entopic endometrium, endometriosis, and ovarian carcinoma were observed. In addition, the down-regulations of MMR proteins were observed in cultured normal endometrial glandular cells under the condition with inflammatory cytokines(TNF-α, IL-6). These findings suggest that mismatch repair abnormalities, which are induced by inflammation, might be involved in the malignant transformation of ovarian endometriosis.
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Research Products
(11 results)
