2011 Fiscal Year Final Research Report

Development and analysis of a novel preeclampsia model using a placenta-specific gene manipulation method.

Research Project

Project/Area Number	22791528
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Obstetrics and gynecology
Research Institution	Hokkaido University
Principal Investigator	MORIOKA Yuka 北海道大学, 遺伝子病制御研究所, 特任助教 (00360264)
Project Period (FY)	2010 – 2011
Keywords	妊娠高血圧症候群 / 胎盤 / レンチウイルスベクター
Research Abstract	Previously, we established a placenta-specific gene manipulation method. Applying this technology, we expressed soluble VEGF receptor 1(sFLT1) known as an anti-angiogenic factor, specifically in the murine placenta. The mice showed hypertension and proteinuria during pregnancy. These are similar symptoms of human preeclampsia patients. We further showed that pravastatin induced the VEGF-like angiogenic factor placental growth factor(PGF) and ameliorated the symptoms.

(1 results)