2011 Fiscal Year Final Research Report
Identification of molecular targeting markers of uterine carcinosarcoma by tissue microarray slides
| Project/Area Number |
22791540
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SAWADA Morio 京都府立医科大学, 医学研究科, 助教 (60573748)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 癌 / 病理学 / トランスレーショナルリサーチ |
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| Research Abstract |
We comprehensively analyzed EGFR and HER-2 overexpression in uterine carcinosarcoma by tissue microarray slides to investigate whether EGFR and HER-2 oncoproteins are molecular targeting markers of uterine carcinosarcoma. EGFR oncoprotein tended to be overexpressed strongly in the mesenchymal component, and overexpression of EGFR oncoprotein tended to increase proportionally to the grading of endometrioid adenocarcinoma increase in the epithelial component. This study may suggest that EGFR oncoprotein is a molecular targeting marker of uterine carcinosarcoma.
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Research Products
(15 results)
