MicroRNA as a new target for ovarian cancer therapy

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791542
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Saitama Medical University
• Principal Investigator: HASEGAWA Kosei 埼玉医科大学, 医学部, 講師 (30534193)
• Project Period (FY): 2010 – 2011
• Keywords: 婦人科腫瘍学 / マイクロRNA

Research Abstract

To determine if the microRNA would be the therapeutic targets for ovarian cancer, we investigated the biological function of the microRNA in ovarian cancer. We observed increased proliferation in ovarian cancer cells with mir-182 overexpression, and less CD8 T lymphocytes infiltration with high mir-182 expressing ovarian cancers. These findings might contribute to the prognosis of ovarian cancer patients. The microRNA is therefore a candidate of new class targets for ovarian cancer.

Research Products

• [Journal Article] Intravenous/intraperitoneal paclitaxel and intraperitoneal carboplatin in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma : a feasibility study (2012)
  • Author(s): Nagao S, Iwasa N, Kurosaki A, Nishikawa T, Ohishi R, Hasegawa K, Goto T, Fujiwara K
  • Journal Title: Int J Gynecol Cancer Volume: 22(1) Pages: 70-5
  • Peer Reviewed
• [Journal Article] Single nedaplatin treatment as salvage chemotherapy for platinum/taxane-resistant/refractory epithelial ovarian, tubal and peritoneal cancers (2010)
  • Author(s): Goto T, Takano M, Ohishi R, Iwasa N, Shimizu M, Hasegawa K, Nagao S, Fujiwara K
  • Journal Title: J Obstet Gynaecol Res Volume: 36(4) Pages: 764-8
  • Peer Reviewed
• [Journal Article] Spontaneously ruptured endometrioma associated with endometrioid adenocarcinoma : MR findings (2010)
  • Author(s): Kozawa E, Matsuo Y, Hasegawa K, Fujiwara K, Sakurai T, Kimura F
  • Journal Title: Magn Reson Med Sci Volume: 9(4) Pages: 233-6
  • Peer Reviewed
• [Presentation] シンポジウム:がん薬物療法のバイオマーカー-婦人科がん (2011)
  • Author(s): 長谷川幸清
  • Organizer: 第49回日本癌治療学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-27
• [Presentation] 健常人末梢血単核球を用いたカツマキソマブのin vitroにおける抗腫瘍効果の検討 (2011)
  • Author(s): 長谷川幸清
  • Organizer: 第50回日本婦人科腫瘍学会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-23
• [Presentation] 婦人科がんに対する維持化学療法のエビデンス構築に向けて (2011)
  • Author(s): 長谷川幸清
  • Organizer: 第9回山形骨盤外科研究会
  • Place of Presentation: 山形
  • Year and Date: 2011-01-22
• [Book] 婦人科系がん免疫細胞治療II (2011)
  • Author(s): 長谷川幸清
  • Total Pages: 184-189
  • Publisher: 幻冬舎
• [Remarks]
  • URL: http://www.saitama-med.ac.jp/kokusai/fujinshuyo/research/index.html