2011 Fiscal Year Final Research Report
Analysis of ALDH1 activity in stem cells of endometrium and endometrial cancer
| Project/Area Number |
22791549
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Juntendo University |
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Principal Investigator |
SUGA Shin 順天堂大学, 医学部, 助教 (70445542)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Kiyoko 順天堂大学, 医学研究科, 准教授 (10253527)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 子宮内膜 / 子宮体癌幹細胞 / side population ALDH1 |
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| Research Abstract |
Primary cultured cells derived from normal human endometrium contained ALDH1-high population. There was no difference of expression of HER2 between ALDH-high cells and. low cells. ALDH1 activity was enhanced in endometrial cancer stem cells compared with that in non-stem cells. Introduction of dbpC to endometrial cancer cells enhanced subpopulations of stem cells as well as the level of ALDH1 ecpression. These results demonstrated that ALDH1 was a candidate for marker of endometrial cancer stem cells.
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[Journal Article] 子宮内膜症ダグラス窩深部病変から発生したと考えられる腺癌の一例2010
Author(s)
寺尾泰久, 須賀新, 楠木総司, 木村美葵, 荻島大貴, 加藤聖子, 竹田省, 正岡亜希子, 樋野興夫, 福村由紀, 八尾隆史
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Journal Title
日本産科婦人科学会関東連合地方部会誌
Volume: 47
Pages: 149-156
Peer Reviewed
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