2011 Fiscal Year Final Research Report
Expression of Ovary-Specific Acidic Protein in Steroidogenic Tissues : A Possible Role in Steroidogenesis
| Project/Area Number |
22791550
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University (2011)
Tokai University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | ステロイド産生 / ミトコンドリア / OSAP / アポトーシス |
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| Research Abstract |
Our results indicate that the mitochondrial protein OSAP is abundantly expressed in steroidogenic tissues with a few exceptions. The results also suggest that OSAP is involved in steroidogenesis. However, our findings point to a permissive role for OSAP in steroidogenesis rather than a regulatory role because OSAP expression was not stimulated by a cAMP analog. Thus, we speculate that this protein could be involved in insuring optimal steroidogenesis through maintaining mitochondrial abundance and/or function. Further studies are warranted to substantiate this postulated role for OSAP in steroidogenic cells.
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