2012 Fiscal Year Final Research Report
Expression and functional analysis of miRNAs in human placenta:molecular and cellar research of IUGR
| Project/Area Number |
22791553
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
KIKUCHI Kunio 日本医科大学, 医学部, 講師 (70374676)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 産科学 |
|---|
| Research Abstract |
The microRNAs (miRNAs) derived from the chromosome 19 miRNA cluster (C19MC) are exclusively expressed in the human placenta. The C19MC miRNAs examined in this study were predominantly expressed in villous trophoblast. Furthermore, we revealed that protein phosphatase 3, regulatory subunit B, alpha (PPP3R1), was a one of C19MC target using an in vitro experimental validation system. These data suggest that C19MC miRNAs is involved in the fine tuning of the Ca2+/calcineurin /NFAT (nuclear factor of activated T-cells) pathway in the villous trophoblast of the human placenta.
|
Research Products
(19 results)
-
[Journal Article] SnoN/SKIL modulates proliferationthrough control of hsa-miR-720 transcription in esophageal cancer cells.2011
Author(s)
Eriko Shinozuka, Masao Miyashita, Yoshiaki Mizuguchi, Ichiro Akagi, Kunio Kikuchi, Hiroshi Makino, Takeshi Matsutani, Nobutoshi Hagiwara, Tsutomu Nomura, Eiji Uchida, Toshihiro Takizawa.
-
Journal Title
Biochemical and Biophysical Research Communications
Volume: 430(1)
Pages: 101-106
DOI
Peer Reviewed
-
-
[Journal Article] Relationship between altered expression levels of MIR21, MIR143,MIR145,and MIR205 and clinicopathologic features of esophageal squamous cell carcinoma.2011
Author(s)
Ichiro Akagi, Masao Miyashita, Osamu Ishibashi, Takuya Mishima, Kunio Kikuchi, Hiroshi Makino, Tsutomu Nomura, Nobutoshi Hagiwara, Eiji Uchida, Toshihiro Takizawa.
-
Journal Title
Diseases of the Esophagus
Volume: 24(7)
Pages: 523-530
DOI
Peer Reviewed
-
-
[Presentation] 絨毛外栄養膜における接着分子CD442012
Author(s)
高橋宏典,菊池邦生,大口昭英,薄井里英,桑田知之,松本久宣,佐藤幸保,藤原浩,松原茂樹,鈴木光明,瀧澤俊広
Organizer
浸潤能の検討第27回日本生殖免疫学会総会・学術集会
Place of Presentation
大阪府大阪市
Year and Date
2012-12-09
-
-
[Presentation] CD44 accelerates trophobalstic invasion: in vitro invasion analysis using HTR8/SVneo cells2012
Author(s)
Hironori Takahashi, Kunio Kikuchi, Tomoyuki Kuwata, Rie Usui, Akihide Ohkuchi, Hisanori Matsumoto, Yukiyasu Sato, Hiroshi Fujiwara, Kumiko Ui-Tei, Shigeki Matsubara, Mitsuaki Suzuki1, Toshihiro Takizawa
Organizer
IFPA 2012 Hiroshima Meeting
Place of Presentation
広島県広島市
Year and Date
2012-09-20
-
-
-
-
-
[Presentation] 食道扁平上皮癌におけるmiRNA発現と臨床病理学的意義の検討2012
Author(s)
篠塚恵理子,宮下正夫,水口義昭,赤城一郎,菊池邦生,萩原信敏,松谷毅,牧野浩司,野村務,瀧澤俊広,内田英二
Organizer
第112回日本外科学会定期学術集会
Place of Presentation
千葉県幕張市
Year and Date
2012-04-13
-
-
-
-
-
-
[Presentation] 胎盤由来エクソソームを介した胎盤-母体間コミュニケーション2011
Author(s)
菊池邦生,アリモハメド,羅善順,石橋宰,石川朋子,瀧澤敬美,倉品隆平,石川源,右田真,大口昭英,松原茂樹,竹下俊行,瀧澤俊広
Organizer
第19回日本胎盤学会学術集会
Place of Presentation
東京都
Year and Date
2011-09-30
-
