2012 Fiscal Year Final Research Report
activation of micro-RNA in head and neck cancer cell
| Project/Area Number |
22791561
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
KANO Satoshi 北海道大学, 大学院・医学研究科, 助教 (00374421)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 頭頸部癌 / マイクロRNA / TRIM32 |
|---|
| Research Abstract |
has-miR-134 was identified as a micro RNA specifically binding to TRIM32. has-miR-134 has been reported to express highly in tongue cancer. VEGF-A and ABCC1 were considered as the target gene of has-miR-134. However, we could not confirm an activation of has-miR-134 by TRIM32. Furthermore, we could not confirm an activation and change in the expression level of has-miR-134 in cell lines overexpressed or knocked down TRIM32.
|
