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2011 Fiscal Year Final Research Report

Development of new therapy to activate anti-tumor immunity against head and neck squamous cell carcinoma

Research Project

  • PDF
Project/Area Number 22791569
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionChiba University

Principal Investigator

SAKURAI Daiju  千葉大学, 大学院・医学研究院, 講師 (10375636)

Project Period (FY) 2010 – 2011
Keywords頭頸部癌 / 腫瘍免疫 / 免疫抑制
Research Abstract

In this research, we performed exploratory studies of MDSC (myeloid-derived suppressor cells) in patients with head and neck cancer. MDSC in PBMC (peripheral blood mononuclear cells) fraction increased significantly in patients with head and neck squamous cell carcinoma (HNSCC) than that in healthy control. When CD15(+) MDSC was depleted from PBMC fraction, T-cell activation was enhanced. The proportion of MDSC in PBMC was negatively correlated with the proportion of lymphocytes in white blood cells. Especially, the negative correlation was found between the proportion of MDSC in PBMC and the proportion of T-cell in PBMC. Therefore it is suggested that MDSC suppress antitumor immunity by accumulation in patients with head and neck cancer and by decreasing T-cell number and suppressing T-cell activation. Development of therapies targeted to MDSC is thought to be a possible new strategy to activate antitumor immunity in patients with head and neck cancer.

  • Research Products

    (3 results)

All 2012 2011

All Presentation (3 results)

  • [Presentation] 頭頸部癌における腫瘍免疫抑制機構の検討2012

    • Author(s)
      櫻井大樹
    • Organizer
      第30回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      滋賀県
    • Year and Date
      2012-02-17
  • [Presentation] 頭頸部扁平上皮癌で増加する骨髄由来抑制細胞による腫瘍免疫抑制機構の解析2011

    • Author(s)
      櫻井大樹
    • Organizer
      第112回日本耳鼻咽喉科学会総会学術講演会
    • Place of Presentation
      京都府
    • Year and Date
      2011-05-19
  • [Presentation] 頭頸部癌患者における骨髄由来抑制細胞の検討2011

    • Author(s)
      櫻井大樹
    • Organizer
      第29回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大分県
    • Year and Date
      2011-02-12

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Published: 2013-07-31  

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