Molecular network analysis of salivary duct carcinoma for the control of distant metastasis

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791570
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Chiba Cancer Center (Research Institute)
• Principal Investigator: SASAKI Keita 千葉県がんセンター(研究所), 医療局頭頸科, 部長 (50400940)
• Project Period (FY): 2010 – 2011
• Keywords: 唾液腺導管癌 / microRNA / マイクロアレイ

Research Abstract

From the results of microRNA array(four pairs of the salivary duct carcinoma and normal salivary gland region), expressions of miR-21 and miR-23-24-27 cluster which have been reported as oncomiRs were increased, whereas expressions of miR-375, miR-1, and miR-200 family which have been reported as tumor suppressive miRNAs were decreased. In order to analyze the gene(s) regulated by miR-200 family, we performed in silico analysis with miRNA target search program and pathway analysis. The results suggested that genes regulated by miR-200 family are involved in cell adhesion. Furthermore, collated focal adhesion-related genes with the microarray analysis of clinical samples, over-expressed genes in cell adhesion may be involved in distant metastasis that is the clinical features of salivary duct carcinoma. These results suggested that the over-expressed genes in cell adhesion might be potential targets of novel treatment for improving the poor prognosis.