2011 Fiscal Year Final Research Report
Molecular network analysis of salivary duct carcinoma for the control of distant metastasis
Project/Area Number |
22791570
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
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Research Institution | Chiba Cancer Center (Research Institute) |
Principal Investigator |
SASAKI Keita 千葉県がんセンター(研究所), 医療局頭頸科, 部長 (50400940)
|
Project Period (FY) |
2010 – 2011
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Keywords | 唾液腺導管癌 / microRNA / マイクロアレイ |
Research Abstract |
From the results of microRNA array(four pairs of the salivary duct carcinoma and normal salivary gland region), expressions of miR-21 and miR-23-24-27 cluster which have been reported as oncomiRs were increased, whereas expressions of miR-375, miR-1, and miR-200 family which have been reported as tumor suppressive miRNAs were decreased. In order to analyze the gene(s) regulated by miR-200 family, we performed in silico analysis with miRNA target search program and pathway analysis. The results suggested that genes regulated by miR-200 family are involved in cell adhesion. Furthermore, collated focal adhesion-related genes with the microarray analysis of clinical samples, over-expressed genes in cell adhesion may be involved in distant metastasis that is the clinical features of salivary duct carcinoma. These results suggested that the over-expressed genes in cell adhesion might be potential targets of novel treatment for improving the poor prognosis.
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