2012 Fiscal Year Final Research Report
Investigation for the pathogenic mechanism of the sensorineural hearing loss of PMP gene
| Project/Area Number |
22791576
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 内耳 / マウス / ヒト側頭骨 / PMP 遺伝子 |
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| Research Abstract |
We investigated the isolation and molecular mechanism of the PMP gene in the inner ear and cochlear dysfunction in order to solve the mechanism of the sensorineural hearing loss for Charcot-Marie-Tooth disease . Although the portion close to the outer hair cells of the animal models demonstrated intense immunohistochemical reaction by the anti-pmp antibody using confocal laser scanning microscopy, we could not identify thespecification of localization in the organ of Corti and the cause of hearing loss.
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