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2011 Fiscal Year Final Research Report

Influence between genetic variant of oxidative stress relating gene CYP1A1 and allergic rhinitis

Research Project

  • PDF
Project/Area Number 22791583
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionUniversity of Fukui

Principal Investigator

SAKASHITA Masafumi  福井大学, 医学部・附属病院, 助教 (40555455)

Research Collaborator FUJIEDA Shigeharu  福井大学, 医学部, 教授 (30238539)
Project Period (FY) 2010 – 2011
Keywords鼻科学 / 鼻アレルギー
Research Abstract

Oxidative stress is one of a key components of inflammation for upper airway diseases. Diesel exhaust particles(DEP) and asian sand dust increase oxidative stress and influence upper airway disorder including allergic rhinisis. Cytochrom 1A1(CYP1A1) is one of the Cytochrome P450 enzymes, catalyze the biotransformation of a wide variety of xenobiotic compaounds such as DEP and asian sand dust. We screened single-nucleotide polymorphisms(SNPs) at the CYP1A1 locus and performed an association study in the Japanese population.(619 patients with allergic rhinitis, 311 controls) Functional analysis of the SNP using transient transfection reporter gene assay was conducted. We identified 9SNPs at this locus and found this region consisted of one linkage disequilibrium block represented by three SNPs(tag SNPs). The association between the intron 1 polymorphism in the CYP1A1 gene and adult allergic rhinitis was significant.(p=0. 002, OR=1. 51, 95% C. I.=1. 1-1. 7) Risk allele containing construct showed significantly lower induction of CYP1A1 promoter activity in reporter gene assay.(p<0. 01) Our results support a role for CYP1A1 in the pathogenesis of allergic rhinitis in the Japanese population.

  • Research Products

    (10 results)

All 2011

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] V.アレルギー性鼻炎のゲノム解析の現況2011

    • Author(s)
      坂下雅文、藤枝重治
    • Journal Title

      アレルギー・免疫

      Volume: Vol.18, No.9 Pages: 38-46

  • [Journal Article] 花粉症の遺伝~子供に花粉症は遺伝するのか?~2011

    • Author(s)
      坂下雅文、藤枝重治
    • Journal Title

      チャイルドヘルス

      Volume: Vol.15, No.2 Pages: 8-12

  • [Journal Article] 免疫療法の作用メカニズム2011

    • Author(s)
      藤枝重治, 坂下雅文, 窪誠太, 大澤陽子
    • Journal Title

      喘息

      Volume: 24(1) Pages: 2-7

  • [Journal Article] Variants of C-C motif chemokine 22(CCL22) are associated with susceptibility to atopic dermatitis : case-control studies2011

    • Author(s)
      Hirota T, Sakashita M(25人中6番目), Yamada T, Fujieda S, Tamari M.
    • Journal Title

      PLoS One

      Volume: 6(11) Pages: e26987

    • DOI

      DOI:10.1371/journal.pone.0026987

    • Peer Reviewed
  • [Journal Article] B type CpG-DNA suppresses poly(I : C)-induced BLyS expression and production in human tonsillar fibroblasts2011

    • Author(s)
      Yamada T, Jiang X, Kubo S, Sakashita M(8人中4番目), Narita N, Yamamoto H, Sunaga H, Fujieda S.
    • Journal Title

      Clin Immunol

      Volume: 141(3) Pages: 365-71

    • DOI

      DOI:10.1016/j.clim.2011.09.012

    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations2011

    • Author(s)
      Noguchi E, Hirota T, Sakashita M(34人中6番目), Fujieda S.
    • Journal Title

      PLoS Genet

      Volume: 7(7) Pages: e1002170

    • DOI

      DOI:10.1371/journal.pgen.1002170

    • Peer Reviewed
  • [Presentation] Association between genetic variant of interleukin(IL)-33 and allergic rhinitis in the Japanese population2011

    • Author(s)
      Masafumi Sakashita, ほか6名
    • Organizer
      XIVIRS-XXXISIAN
    • Place of Presentation
      東京
    • Year and Date
      20110920-23
  • [Presentation] The impact of Asian sand Dust on allergic rhinitis2011

    • Author(s)
      Masafumi Sakashita, ほか8名
    • Organizer
      第42回日本職業・環境アレルギー学会総会・学術大会
    • Place of Presentation
      愛知
    • Year and Date
      20110603-04
  • [Presentation] スギ花粉症患者の症状への黄砂の影響2011

    • Author(s)
      坂下雅文, ほか6名
    • Organizer
      第23回日本アレルギー学会春季臨床大会一般講演(ポスター)
    • Place of Presentation
      千葉
    • Year and Date
      20110514-05
  • [Presentation] スギ特異的舌下免疫療法の治療効果に相関するマーカー分子の検討(2)2011

    • Author(s)
      坂下雅文, ほか6名
    • Organizer
      第29回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大分
    • Year and Date
      20110210-12

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Published: 2013-07-31  

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