2011 Fiscal Year Final Research Report
Hedgehog signali ng regulates middle and external ear development
Project/Area Number |
22791596
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
|
Research Institution | Kyoto University |
Principal Investigator |
KADA Shinpei 京都大学, 医学研究科, 医員 (70543263)
|
Project Period (FY) |
2010 – 2011
|
Keywords | 中耳 / 外耳 / 発生 / ヘッジホッグ |
Research Abstract |
Hedgehog signaling is reported to play important roles in morphogenesis in the developmental stage of various organs. However, little is known about the roles of hedgehog signaling in the development of middle and external ear. We have developed Emx2(+/Cre); Rosa26SmoM2 transgenic mice, which overexpress hedgehog signaling in a target organ, and found anomaly of the external ear, which suggests that hedgehog signaling plays some role in the development of the external ear.
|