2012 Fiscal Year Final Research Report
Regeneration study of olfactory epithelium and olfactory bulb using bone marrow cells
| Project/Area Number |
22791603
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 再生医学 / 細胞・組織 / シグナル伝達 / 脳・神経 |
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| Research Abstract |
This study was conducted to promote regeneration of olfactory organ with the aim to establish the regenerative therapy in rhinology, using bone marrow cells. As a result, valproic acid (antiepileptic drug) promoted transcriptional activation in regeneration of olfactory bulb, and it was suggested that valproic acid had possibility to recover neuronal cell-producing capacity. Also,the use of cytokine is effective for long-term olfaction disorder. However, it was suggested about the differentiation instruction to the neuronal cells of the bone marrow cells that the examination of a new factor was necessary.
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