Regulation mechanism of antigen recognition by controlling the interaction of dendritic cells and mucosal cells in the epithelium

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791615
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Sapporo Medical University
• Principal Investigator: KUROSE Makoto 札幌医科大学, 医学部, 助教 (60404696)
• Project Period (FY): 2010 – 2011
• Keywords: 特異的免疫療法 / 樹状細胞 / テロメラーゼ遺伝子導入培養ヒト粘膜上皮細胞

Research Abstract

Nasopharynx and nasal mucosa are located at the forefront of the host defense against foreign pathogens, which plays an important role in acquired immunity and innate immunity. To elucidate the immune system of allergy infection, we analyzed the mechanism of epithelial barrier function and antigen presentation in the nasal epithelium of human nasopharyngeal epithelium. In addition, we made a research on the interaction of dendritic cells and mucosal epithelium.

Research Products

• [Journal Article] Mucosal immune barrier and antigen-presenting system in human nasal epithelial cells (2011)
  • Author(s): Himi T, Takano K, Ogasawara N, Go M, Kurose M, Koizumi J, Kamekura R, Kondo A, Ohkuni T, Masaki T, Kojima T, Sawada N, Tsutsumi H
  • Journal Title: Adv Otorhinolaryngol Volume: 72 Pages: 28-30
  • Peer Reviewed
• [Journal Article] Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids (2011)
  • Author(s): Ogasawara N, Kojima T, Takano K, Kamekura R, Ohkuni T, Koizumi J, Masaki T, Fuchimoto J, Obata K, Kurose M, Shintani T, Sawada N, Himi T
  • Journal Title: Acta Otolaryngol Volume: 131(2) Pages: 116-23
  • Peer Reviewed