2011 Fiscal Year Final Research Report

Study on the serotypes and specific immune response of Streptococcus pneumonia in acute otitis media.

Research Project

Project/Area Number	22791624
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Wakayama Medical University
Principal Investigator	IKEDA Yorihiko 和歌山県立医科大学, 医学部, 助教 (20423949)
Project Period (FY)	2010 – 2011
Keywords	急性中耳炎 / 肺炎球菌 / 血清型
Research Abstract	Streptococcus pnenmoniae is a leading cause of acute otitis media. S. pnenmoniae typically colonizes the human nasopharynx. Among 202 S. pnenmoniae isolates from the uuper respiratory tract infections(URT), we were determined serotype 19F(19. 4%), serotype 23F(14. 9%), serotype 14(11. 4%), serotype 6B(11. 4%), serotype 6A(9. 1%), serotype 3(9. 1%). All strains of serotype 3 were penicillin susceptible S. pnenmoniae(PSSP), on the other hand, strains of serotype 19F and serotype 23F were predominant in penicillin resistant S. pnenmoniae(PRSP) or penicillin intermediately resistant S. pnenmoniae(PISP). The coverage of S. pnenmoniae vaccine were 7-valent pneumococcal conjugate vaccine(7-PCV, 60. 6%), 11-PCV(61. 7%), 13-PCV(82. 9%), PPV(82. 9%) respectively.