2012 Fiscal Year Final Research Report
Research of miRNA function in inner ear disease and new diagnostic biomarker
| Project/Area Number |
22791636
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SEKINE Kuwon 日本医科大学, 医学部, 助教 (20566377)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 内耳 / miRNA / マイクロアレイ / 高齢者 |
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| Research Abstract |
miRNAs are small non-coding RNAs. They are involved in diverse physiological, developmental, and pathological processes by regulating the expression of target messenger RNAs (mRNAs). In the current review, they discuss the developments in miRNAs research with a focus on the potential role of miRNAs in inner ear development, genetic hearing loss. In this study we examined miRNAs expression in plural geriatric human inner ear. In this research we found that these miRNAs that have a important roles in inner ear, are still expressed in old age, and oldest olds. This result shows that these miRNAs have important roles not only in development but also in inner ear maintenance of homeostasis.
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Research Products
(6 results)
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[Journal Article] Cochlin-tomoprotein (CTP) detection test identifies traumatic perilymphatic fistula due to penetrating middle ear injury.2011
Author(s)
Ikezono T, Shindo S, Sekine K, Shiiba K, Matsuda H, Kusama K, Koizumi Y, Sugizaki K, Sekiguchi S, Kataoka R, Pawankar R, Baba S, Yagi T, Okubo K.
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Journal Title
Acta Otolaryngol
Volume: 131巻
Pages: 937-944
DOI
Peer Reviewed
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