2011 Fiscal Year Final Research Report
Evaluation of effect of simultaneous hypervaric oxygen therapy and edaravone for inner ear ischemic diseases in animal models.
| Project/Area Number |
22791637
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
INUI Takaki 大阪医科大学, 医学部, 助教 (60465614)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 蝸牛内直流電位 / 高圧酸素療法 / エダラボン / 内耳虚血 |
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| Research Abstract |
Ischemia is one of the possible pathological conditions causing sudden deafness. The endolymphatic application with PKC inhibitors significantly suppressed the decrease in the EP induced by transient asphyxia. Furthermore, endolymphatic application with PKC activator caused large decrease in the EP. These results indicate that decrease in the EP induced by asphyxia is the result of PKC activation in the stria vascularis.
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