2011 Fiscal Year Final Research Report
Effect of menthol on patients with rhinitis and rhinosinus it is
| Project/Area Number |
22791638
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
TSUZUKI Kenzo 兵庫医科大学, 医学部, 講師 (50441308)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アレルギー性鼻炎 / 慢性副鼻腔炎 / 嗅覚障害 / 鼻腔内ポリープ / 内視鏡下鼻副鼻腔手術 / 下鼻甲介手術 / メントール |
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| Research Abstract |
Patients with rhinitis and rhinosinusitis were analyzed in this study. Olfactory function in the patients was examined using self-administered odor questionnaire(SAOQ), alternative open essence test(OE) recently developed in Japan, T & T olfactometer and intravenous olfaction test. Most patients who underwent endoscopic sinus surgery(ESS) had severe olfactory disorders. We reported a clinical availability of the SAOQ. Menthol was identified in more than half of them even on the preoperative OE test. The mean OE scores, T & T recognition thresholds improved after ESS. Possibility of action of the ligand of menthol via not only somatosensory but also olfactory nerves was suggested.
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