2012 Fiscal Year Final Research Report
Analysis of ZNF143 as a Th2 cytokine regulator in allergic rhinitis
| Project/Area Number |
22791640
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 転写因子 / ZNF143 / Th2サイトカイン / アレルギー性鼻炎 / 好酸球 |
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| Research Abstract |
The expression level of ZNF143 mRNA in human nasal mucosa had significant correlation between IL-5 mRNA, IL-13 mRNA, and the total IgE. This is the result of showing that ZNF143 is participating in the allergic rhinitis through the transcriptional regulation of Th2 cytokines. We consider ZNF143 interacts with GATA-3 and involved in the regulation of the Th2 cytokines.
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