2011 Fiscal Year Final Research Report
Development of uveitis therapy with control for CD4+CD25+regulatory T cells
| Project/Area Number |
22791646
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
HORIE Yukihiro 北海道大学, 大学院・医学研究科, 客員研究員 (80547183)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ぶどう膜炎 / 調節性T細胞 |
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| Research Abstract |
The purpose of this investigation was to make clear the role and function of regulatory T cells(Treg) expressing folate receptor 4(FR4) which was recently known as a new marker of Tregs, on experimental autoimmune uveoretinitis(EAU) which is an animal model of human uveitis. As suppression of Tregs by administration of anti-FR4 antibody in EAU mouse, the severity of EAU tended to be increased. This result suggested that Tregs expressing FR4 had a role to suppress intraocular inflammations.
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