2011 Fiscal Year Final Research Report
Intraocular Concentrations of Cytokines and Chemokines in Rhegmatogenous Retinal Detachment and the Effect of Intravitreal Triamcinolone Acetonide
| Project/Area Number |
22791648
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | サイトカイン / ケモカイン / 硝子体 / ステロイド / トリアムシノロンアセトニド / MCP-1 / 網膜剥離 |
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| Research Abstract |
To determine the aqueous humor levels of chemokines before and after an intravitreal injection of triamcinolone acetonide (IVTA)in eyes with rhegmatogenous retinal detachment (RRD).
Nineteen eyes of 19 consecutive patients with RRD who underwent IVTA were studied. 17 eyes without retinal vascular disease served as control.
The aqueous humor levels of interleukin-6 (IL-6), IL-8, eotaxin, G-CSF, GM-CSF, IFN-gamma, IP-10, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 alpha (MIP-1a), beta (MIP-1b), RANTES, TNF-alpha and vascular endothelial growth factor (VEGF)were determined before the IVTA (baseline)and at one day after the IVTA.
At the baseline, IL-6, IL-8, IP-10, MCP-1, MIP-1b and VEGF were detected in the aqueous and were significantly higher in eyes with a RRD than in controls. One day after IVTA, the levels of IP-10, MCP-1 and MIP-1b were significantly reduced and the decreases in IP-10, MCP-1 and MIP-1b were correlated. IVTA was able to suppress the levels of IP-10, MCP-1 and MIP-1b in eyes with RRD. The alterations in the aqueous level of IP-10, MCP-1 and MIP-1b were similar and these chemokines might potentially be additional target molecules in therapy for RRD.
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