2011 Fiscal Year Final Research Report
Research of Cotylenin A functions in retinoblastoma cells
| Project/Area Number |
22791649
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Yonezawa women's junior college (2011)
Yamagata University (2010) |
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Principal Investigator |
KASHIWAGI Yoshiko 山形県立米沢女子短期大学, その他部局等, 助手 (90375345)
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| Project Period (FY) |
2010 – 2011
|
| Keywords | コチレニン A / 網膜芽細胞腫 / 神経節細胞 / 抗腫瘍 / 神経保護 |
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| Research Abstract |
We found that Cotyelenin A is a potent inhibitor of cell proliferation and apoptosis, and it changes tumor characteristics in retinoblastoma cell lines. Differences in the effect of Cotyelenin A on ocular retinoblastoma tumors and metastatic tumours were observed. However, we could not detect the function of nerves protection in rat retina ganglion cells (RGC5).
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