Comprehensive Assessment for improvement of QOL and effectiveness brought by AMD treatment.

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791655
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: TAMURA Hiroshi 京都大学, 医学研究科, 助教 (40418760)
• Project Period (FY): 2010 – 2011
• Keywords: 加齢黄斑変性 / QOL / 脈絡膜新生血管

Research Abstract

New findings of age-related macular degeneration or its relative disease such as central serous chorioretinopathy and choroidal neovascularization secondary to angioid streaks are found to understand the pathophysiologies of these desease. Experiences in comparative effectiveness research for cataract surgery were successfully applied to age-related macular degeneration treatment. New findings of effectiveness in treatment for AMD were also revealed from the relationship between second eye involvement of AMD and ARMS2 genotype.

Research Products

• [Journal Article] Factors Associated with the Response of Age-related Macular Degeneration to Intravitreal Ranibizumab Treatment (2012)
  • Author(s): Yamashiro K, Tomita K, Tsujikawa A, Nakata I, Akagi-Kurashige Y, Miyake M, Ooto S, Tamura H, Yoshimura N.
  • Journal Title: Am J Ophthalmol
  • DOI: DOI:10.1016/j.ajo.2012.01.010
  • Peer Reviewed
• [Journal Article] Relationship between retinal morphological findings and visual function inage-related macular degeneration (2012)
  • Author(s): Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol
  • DOI: DOI:10.1007/s00417-012-1928-5
  • Peer Reviewed
• [Journal Article] Treatment of Polypoidal Choroidal Vasculopathy with Photodynamic Therapy Combined with Intravitreal Injections of Ranibizumab (2012)
  • Author(s): Tomita K, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Otani A, Nakayama Y, Yoshimura N.
  • Journal Title: Am J Ophthalmol Volume: 153(1) Pages: 68-80
  • DOI: DOI:10.1007/s00417-012-1928-5
  • Peer Reviewed
• [Journal Article] Eye Care Comparative Effectiveness Research Team(ECCERT). Cost-effectiveness of cataract surgery in Japan (2011)
  • Author(s): Hiratsuka Y, Yamada M, Murakami A, Okada AA, Yamashita H, Ohashi Y, Yamagishi N, Tamura H, Fukuhara S, Takura T
  • Journal Title: Jpn J Ophthalmol Volume: 55(4) Pages: 333-42
  • DOI: DOI:10.1007/s10384-011-0041-3
  • Peer Reviewed
• [Journal Article] Association of Lesion Size and Visual Prognosis to Polypoidal Choroida Vasculopathy (2011)
  • Author(s): Tsujikawa A, Ojima Y, Yamashiro K, Nakata I, Ooto S, Tamura H, Nakanishi H, Hayashi H, Otani A, Yoshimura N.
  • Journal Title: Am J Ophthalmol Volume: 151(6) Pages: 961-972
  • DOI: DOI:10.1016/j.ajo.2011.01.002
  • Peer Reviewed
• [Journal Article] Genetic Variants in Pigment Epithelium-Derived Factor Influence Response of Polypoidal Choroidal Vasculopathy to Photodynamic Therapy (2011)
  • Author(s): Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamura H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N.
  • Journal Title: Ophthalmology Volume: 118(7) Pages: 1408-15
  • DOI: DOI:10.1016/j.ophtha.2010.12.011
  • Peer Reviewed
• [Journal Article] Prognostic factors for visual outcomes 2-years after intravitreal bevacizumab for myopic choroidal neovascularization (2011)
  • Author(s): Nakanishi H, Tsujikawa A, Yodoi Y, Ojima Y, Otani A, Tamura H, Yamashiro K, Ooto S, Yoshimura N.
  • Journal Title: Eye(Lond) Volume: 25(3) Pages: 375-81
  • DOI: DOI:10.1038/eye.2010.226
  • Peer Reviewed
• [Journal Article] Development of polypoidal lesions in age-related macular degeneration (2011)
  • Author(s): Tsujikawa A, Ojima Y, Yamashiro K, Ooto S, Tamura H, Nakata I, Yoshimura N.
  • Journal Title: Eye(Lond) Volume: 25(4) Pages: 481-8
  • DOI: DOI:10.1038/eye.2010.232
  • Peer Reviewed
• [Journal Article] Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy (2011)
  • Author(s): Ooto S, Tsujikawa A, Mori S, Tamura H, Yamashiro K, Otani A, Yoshimura N.
  • Journal Title: Retina Volume: 31(3) Pages: 527-34
  • DOI: DOI:10.1097/IAE.ob013e3181eef2db
  • Peer Reviewed
• [Journal Article] Treatment of Polypoidal Choroidal Vasculopathy with Intravitreal Injection of Bevacizumab (2010)
  • Author(s): Tsujikawa A, Ooto S, Yamashiro K, Tamura H, Otani A, Yoshimura N.
  • Journal Title: Jpn J Ophthalmol Volume: 54(4) Pages: 310-9
  • DOI: DOI:10.1007/S10384-010-0813-1
  • Peer Reviewed
• [Journal Article] Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen (2010)
  • Author(s): Iwama D, Tsujikawa A, Ojima Y, Nakanishi H, Yamashiro K, Tamura H, Ooto S, Yoshimura N.
  • Journal Title: Clin Experiment Ophthalmol Volume: 38(5) Pages: 483-8
  • DOI: DOI:10.1111/j.1442-9071.2010.02294.x
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab for type 1 idiopathic macular telangiectasia (2010)
  • Author(s): Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, Yoshimura N.
  • Journal Title: Eye(Lond) Volume: 24(9) Pages: 1492-7
  • DOI: DOI:10.1038/EYE.2010.61
  • Peer Reviewed
• [Journal Article] Idiopathic macular telangiectasia ; microperimetry, retinal structure ; photoreceptor inner and outer segment junction line ; optical coherence tomography.
  • Author(s): Takayama K, Ooto S, Tamura H, Yamashiro K, Otani A, Tsujikawa A, Yoshimura N.
  • Journal Title: Retina Volume: (in press)
  • Peer Reviewed
• [Presentation] 弾性線維性仮性黄色腫症患者の疫学調査ならびにABCC 6遺伝子変異の解析:中間報告I (2011)
  • Author(s): 岩永聰、与崎マリ子、八木洋輔、原肇秀、室賀絵里、谷岡未樹、北岡隆、築城英子、田村寛
  • Organizer: 第43回日本結合組織学会学術大会、第58回マトリックス研究会大会
  • Place of Presentation: 大分
  • Year and Date: 2011-06-10