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2013 Fiscal Year Final Research Report

Study of electrical stimulation therapy for optic neuropathies

Research Project

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Project/Area Number 22791658
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

MORIMOTO Takeshi  大阪大学, 医学(系)研究科(研究院), 准教授 (00530198)

Project Period (FY) 2010-04-01 – 2014-03-31
Keywords神経保護 / 電気刺激治療 / 網膜神経節細胞
Research Abstract

In the present study, I investigated the mechanism underlying electrical stimulation -induced neuroprotection of retinal ganglion cells and examined the effect of electrical stimulation on various optic neuropathies. I elucidated that retinal neurovascular coupling was activated by electrical stimulation to exert neuroprotection. And moreover I found that about 30% of patients improved their vision after electrical stimulation treatment. Finally I established the protocol of electrical stimulation therapy for various optic neuropathies.

  • Research Products

    (30 results)

All 2014 2013 2012 2011 Other

All Journal Article (15 results) Presentation (14 results) (of which Invited: 4 results) Remarks (1 results)

  • [Journal Article] Characteristics of retinal reflectance changes induced by transcorneal electrical stimulation in cat eyes2014

    • Author(s)
      Morimoto T, 他7名
    • Journal Title

      PLoS One

      Volume: 9 Pages: e92186

  • [Journal Article] 内斜視術後患者における3D映像の立体感2013

    • Author(s)
      遠藤 高生, 森本 壮 (3), 他2名
    • Journal Title

      臨床眼科

      Volume: 67 Pages: 1489-1494

  • [Journal Article] 壮年期に発症した視神経乳頭近傍の網膜細動脈瘤破裂の1例2013

    • Author(s)
      浅尾 和伸, 森本 壮(3),他2名
    • Journal Title

      眼科臨床紀要

      Volume: 6 Pages: 725-728

  • [Journal Article] Feasibility of 2nd generation STS retinal prosthesis in dogs2013

    • Author(s)
      Fujikado T, Morimoto T (5), 他9名
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc.

      Volume: 2013 Pages: 3119-3121

  • [Journal Article] Optical imaging of retina in response to grating stimuli in cats2013

    • Author(s)
      Hirohara Y, Morimoto T (4), 他5名
    • Journal Title

      Exp Eye Res

      Volume: 109 Pages: 1-7

  • [Journal Article] Berkeley Rudimentary Vision Test(BRVT)を用いた超低視力の定量化の試み2013

    • Author(s)
      中村美紗子, 森本壮 (6), 他5名
    • Journal Title

      眼科臨床紀要

      Volume: 6 Pages: 49-54

  • [Journal Article] Role of Electrical Activity of Neurons for Neuroprotection2012

    • Author(s)
      Morimoto T
    • Journal Title

      Int Rev Neurobiol

      Volume: 105 Pages: 19-38

  • [Journal Article] Transcorneal Electrical Stimulation Promotes Survival of Photoreceptors and Improves Retinal Function in Rhodopsin P347L Transgenic Rabbits2012

    • Author(s)
      Morimoto T, 他5名
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 53 Pages: 4254-4261

  • [Journal Article] Serial measurements of accommodation by open-field Hartmann-Shack wavefront aberrometer in eyes with accommodative spasm2012

    • Author(s)
      Kanda H, Morimoto T (4), 他4名
    • Journal Title

      Jpn J Ophthalmol

      Volume: 56 Pages: 617-623

  • [Journal Article] Adaptive optics dioptric scanning ophthalmoscope with a wider field of view similar to those of normal ophthalmoscopes2012

    • Author(s)
      Yamaguchi T, Morimoto T (5), 他4名
    • Journal Title

      Opt Lett.

      Volume: 37 Pages: 2496-2498

  • [Journal Article] 【神経眼科-診断から治療へ-】視神経疾患に対する電気刺激療法2012

    • Author(s)
      森本 壮
    • Journal Title

      神経眼科

      Volume: 29 Pages: 276-285

  • [Journal Article] Chronic implantation of newly developed suprachoroidal-transretinal stimulation (STS) prosthesis in dogs2011

    • Author(s)
      Morimoto T, 他11名
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 52 Pages: 6785-6792

  • [Journal Article] Testing of Semi-chronically Implanted Retinal Prosthesis by Suprachoroidal-Transretinal Stimulation in Patients with Retinitis Pigmentosa2011

    • Author(s)
      Fujikado T, Morimoto T(5), 他11名
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 52 Pages: 4726-4733

  • [Journal Article] 本態性眼瞼痙攣診断例におけるドライアイ合併の割合2011

    • Author(s)
      山本定徳, 森本 壮 (2), 他4名
    • Journal Title

      眼科臨床紀要

      Volume: 4 Pages: 738-741

  • [Journal Article] 若年成人におけるピレンゼピン点眼薬の瞳孔および調節に与える影響2011

    • Author(s)
      川口佳菜, 森本 壮 (3), 他6名
    • Journal Title

      眼科臨床紀要

      Volume: 5 Pages: 21-26

  • [Presentation] Feasibility of chronically implanted retinal prosthesis by suprachoroidal-transretinal stimulation in patients with advanced retinitis pigmentosa2011

    • Author(s)
      Morimoto T
    • Organizer
      2nd Korea-Japan SCEV joint meeting
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-11-19
    • Invited
  • [Presentation] GPA(Granulomatosis with Polyangiitis)が疑われた鼻性視神経症の1例

    • Author(s)
      遠藤 高生, 森本 壮, 他3名
    • Organizer
      第51回日本神経眼科学会
    • Place of Presentation
      秋田
  • [Presentation] Evaluating the Relationship between Retinal Damage and Electrical Stimulation Intensity with Suprachoroidal-Transretinal Stimulation

    • Author(s)
      Kanda H, Morimoto T, 他3名
    • Organizer
      3rd International Conference on medicalbionics Engineering Solutinos for Neural Disorders
    • Place of Presentation
      Silverwater Resort, Phillip Island, Australia
  • [Presentation] Feasibility of 2nd Generation STS Retinal Prosthesis in dogs

    • Author(s)
      Fujiakdo T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, 他7名
    • Organizer
      Artificial Vision 2013 : The International Symposium on Visual Prosthetics
    • Place of Presentation
      Aachen, Germany
  • [Presentation] Intraocular Pressure and Retinal Vascular Changes during Transient Exposure to Microgravity in Adult Rats

    • Author(s)
      Morimoto T, 他5名
    • Organizer
      34th Annual Meeting International Gravitational Physiology
    • Place of Presentation
      Toyohashi Japan
  • [Presentation] Evaluation of localization test under simulated very low vision conditions

    • Author(s)
      Endo T, Morimoto T, 他4名
    • Organizer
      ARVO2013 Seattle
    • Place of Presentation
      USA
  • [Presentation] In situ monitoring cytochrome c in dying RGC-5 cells by Raman microscopy

    • Author(s)
      Morimoto T, 他7名
    • Organizer
      ARVO2013 Seattle
    • Place of Presentation
      USA
  • [Presentation] Evaluation of safety of porous surface electrodes for STS Retinal prosthesis

    • Author(s)
      Kanda H, Morimoto T, 他4名
    • Organizer
      ARVO2013 Seattle
    • Place of Presentation
      USA
  • [Presentation] 多孔化処理を施した人工網膜用刺激電極の安全性評価

    • Author(s)
      神田 寛行, 森本 壮, 他4名
    • Organizer
      第117回日本眼科学会
    • Place of Presentation
      東京
  • [Presentation] 超低視力者における到達運動のLocalization testによる評価

    • Author(s)
      遠藤 高生, 森本 壮, 他4名
    • Organizer
      第117回日本眼科学会
    • Place of Presentation
      東京
  • [Presentation] 軸索切断された網膜神経節細胞に対する Peroxiredoxin6 の酸化ストレス防御と神経保護

    • Author(s)
      森本 壮, 他8名
    • Organizer
      第117回日本眼科学会
    • Place of Presentation
      東京
  • [Presentation] 網膜色素変性に対する電気刺激治療

    • Author(s)
      森本 壮
    • Organizer
      第61回日本臨床視覚電気生理学会
    • Place of Presentation
      大阪
    • Invited
  • [Presentation] 難治性視神経疾患の病態と治療

    • Author(s)
      森本 壮
    • Organizer
      第26回大阪市大眼科研究会
    • Place of Presentation
      大阪
    • Invited
  • [Presentation] 難治性視神経疾患に対する治療戦略

    • Author(s)
      森本 壮
    • Organizer
      日本神経眼科学会 50周年記念講演会シンポジウム
    • Place of Presentation
      京都
    • Invited
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/sensory/www/

URL: 

Published: 2015-06-25  

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