2011 Fiscal Year Final Research Report
The involvement of ocular surface barrier in allergic conjunctival diseases
| Project/Area Number |
22791664
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kochi University |
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Principal Investigator |
FUKUDA Ken 高知大学, 教育研究部・医療学系, 准教授 (70335751)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アレルギー / 上皮細胞 / バリアー / サイトカイン / マウス / 角膜 / 結膜 |
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| Research Abstract |
Among Th2 cytokines, IL-4 and IL-13, but not IL-5, IL-9, or IL-10, induced a significant decrease of barrier function in cultured human corneal epithelial cells. In a mouse model of allergic conjunctivitis using ragweed pollen, allergen challenge caused a decrease in expression of the junctional protein, E-cadherin, by conjunctival epithelium.
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