2011 Fiscal Year Final Research Report
Suppression of inflammation with the cornea infection by the control of the natural immunity
| Project/Area Number |
22791666
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kochi University |
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Principal Investigator |
SUMI Tamaki 高知大学, 教育研究部・医療学系, 助教 (70385243)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 角膜感染症 / 緑膿菌 / 角膜炎 / サイトカイン / 好中球 |
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| Research Abstract |
Keratitis was induced by the application of LPS in C57BL/ 6 mice. Time-points of infiltration into cornea differed between macrophages and neutrophils. Similarly, humoral factors such as cytokines and chemokines were detected at different time-point. I made a mouse model of Pseudomonas aeruginosa(P. aeruginosa.) keratitis. Severe keratitis was induced by 5x10^6 of CFU P. aeruginosa.(clinical separation). The average clinical score of keratitis was lower in the BALB/ c than C57BL/ 6 mice.
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Research Products
(23 results)
