The Anti-inflammatory Effect of Resveratrol in Diabetic Retina

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791686
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: KUBOTA Shunsuke 慶應義塾大学, 医学部, 研究員(非常勤) (90406041)
• Project Period (FY): 2010 – 2011
• Keywords: 眼細胞生物学 / 糖尿病網膜症

Research Abstract

Resveratrol is known as one of antioxidant polyphenols. The purpose of the present study was to investigate the effect of resveratrol on the diabetic retina. The diabetic model mice were orally treated with resveratrol for seven days. Administration of resveratrol significantly reduced leukocyte adhesion to the retinal vessels of diabetic mice. In addition, the diabetic animals treated with resveratrol showed a significant decrease in retinal inflammatory molecules, which were upregulated following the induction of diabetes. The current data suggest the potential use of resveratrol as a therapeutic agent for diabetic retinopathy.

Research Products

• [Journal Article] Roles of AMP-Activated Protein Kinase in Diabetes-Induced Retinal Inflammation (2011)
  • Author(s): Kubota S, Ozawa Y, Kurihara T, Sasaki M, Yuki K, Miyake S, Noda K, Ishida S, Tsubota K
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52(12) Pages: 9142-8
  • Peer Reviewed
• [Presentation] 糖尿病網膜症におけるAMPキナーゼの役割 (2011)
  • Author(s): 久保田俊介、小沢洋子、栗原俊英、佐々木真理子、結城賢弥、三宅誠司、野田航介、石田晋、坪田一男
  • Organizer: 第9回日本坑加齢医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-27
• [Presentation] 糖尿病網膜症におけるAMPキナーゼの役割について (2011)
  • Author(s): 久保田俊介、小沢洋子、栗原俊英、佐々木真理子、結城賢弥、三宅誠司、野田航介、石田晋、坪田一男
  • Organizer: 第115回日本眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] Resveratrol Attenuates Diabetes-Induced Retinal Inflammation by Regulating an AMP-Activated Protein Kinase/Nuclear Factor-kappaB Axis (2011)
  • Author(s): Kubota S, Ozawa Y, Kurihara T, Sasaki M, Yuki K, Miyake S, Noda K, Ishida S, Tsubota K
  • Organizer: Association for Research in Vision and Ophthalmology annual meeting at Florida
  • Place of Presentation: U. S. A
  • Year and Date: 2011-05-05
• [Presentation] 糖尿病網膜症に対するSIRT1の抗炎症効果 (2010)
  • Author(s): 久保田俊介、小沢洋子、石田晋、坪田一男
  • Organizer: 第31回日本炎症・再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-05
• [Presentation] Resveratrol suppresses ocular inflammation in the Diabetic retina (2010)
  • Author(s): Kubota S, Kurihara T, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K
  • Organizer: Association for Research in Vision and Ophthalmology annual meeting at Florida
  • Place of Presentation: U. S. A
  • Year and Date: 2010-05-05