2011 Fiscal Year Final Research Report
Mechanism of decreased tear secretion in mice with metabolic syndrome
| Project/Area Number |
22791691
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 細胞生物学 / 涙腺 / ドライアイ / 糖尿病 |
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| Research Abstract |
We demonstrated that tear volume significantly decreased in metabolic syndrome model mice fed with a high fat diet. Inflammatory cell infiltration and inflammatory related gene expression level in the lacrimal glands were significantly increased in the high fat fed group. Immunohistochemistry of the lacrimal glands showed positive staining for 8-OHdG in the high fat group. Metabolic syndrome influences lacrimal gland function in mice, which might be caused by oxidative damage and the subsequent gland inflammation.
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