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2011 Fiscal Year Final Research Report

Phenotypic difference of age-related macular degeneration as determined by single nucleotide polymorphisms

Research Project

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Project/Area Number 22791706
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKyoto University (2011)
Foundation for Biomedical Research and Innovation (2010)

Principal Investigator

OISHI Akio  京都大学, 医学研究科, 助教 (50572955)

Project Period (FY) 2010 – 2011
Keywords遺伝学 / イメージング
Research Abstract

We explored single nucleotide polymorphisms(SNPs), which are associated with development, prognosis, or response to treatment of age-related macular degeneration. We found that 1) SERPINF1 SNPs influence the response to and visual prognosis after photodynamic therapy 2) SERPING1 SNPs have little influence on the development of AMD in Japanese 3) C2/CFB SNPs have protective effect in the risk of developing AMD. In addition, we published several reports concerning the association between optical coherence tomography findings and visual function.

  • Research Products

    (15 results)

All 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population.2012

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanshi H, Hayashi H, Akagi-Kurashige Y, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 53 Pages: 794-798

    • DOI

      DOI:10.1167/iovs.11-8468

    • Peer Reviewed
  • [Journal Article] The significance of cone outer segment tipas as a prognostic factor in epiretinal membrane surgery2012

    • Author(s)
      Shimozono M, Oishi A, Hata M, Matsuki T, Ito S, Ishida K, Kurimoto Y
    • Journal Title

      Am J Ophthalmol

      Volume: 153 Pages: 698-704

    • DOI

      DOI:10.1016/j.ajo.2011.09.011

    • Peer Reviewed
  • [Journal Article] Possible vitreous involvement in a case with rapidly progressing choroidal neovascularization2012

    • Author(s)
      Hata M, Oishi A, Mandai M, Kurimoto Y
    • Journal Title

      Indian J Ophthalmol

      Volume: 60 Pages: 57-58

    • DOI

      DOI:10.4103/0301-4738.91348

    • Peer Reviewed
  • [Journal Article] Bilateral Nonarteritic Anterior Ischemic Optic Neuropathy Following Intravitreal Injection of Pegaptanib2011

    • Author(s)
      Kimakura M, Oishi A, Mandai M, Kurimoto Y
    • Journal Title

      J Clinic Experiment Ophthalmol

      Volume: 2 Pages: 162

    • DOI

      DOI:10.4172/2155-9570.1000162

    • Peer Reviewed
  • [Journal Article] Remission and dropout rate of anti-VEGF therapy for age-related macular degeneration2011

    • Author(s)
      Oishi A, Mandai M, Nishida A, Hata M, Matsuki T, Kurimoto Y
    • Journal Title

      Eur J Ophthalmol

      Volume: 21 Pages: 777-82

    • DOI

      DOI:10.5301/EJO.2011.743

    • Peer Reviewed
  • [Journal Article] Characteristics of fine vascular network pattern before photodynamic therapy associated with recurrence of polypoidal choroidal vasculopathy2011

    • Author(s)
      Oishi A, Mandai M, Kimakura M, Nishida A, Kurimoto Y
    • Journal Title

      Eye(Lond)

      Volume: 25 Pages: 1020-6

    • DOI

      DOI:10.1038/eye.2011.110

    • Peer Reviewed
  • [Journal Article] Restoration of the photoreceptor outer segment and visual outcomes after macular hole closure : spectral-domain optical coherence tomography analysis2011

    • Author(s)
      Shimozono M, Oishi A, Hata M, Kurimoto Y
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 249 Pages: 1469-76

    • DOI

      DOI:10.1007/s00417-011-1681-1

    • Peer Reviewed
  • [Journal Article] Assoication between the SERPING1 gene and age-related macular degeneration and Polypoidal Choroidal Vasculopathy in a Japanese2011

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Gotoh N, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Saito M, Iida T, Oishi A, Matsuo K, Tajima K, Matsuda F, Yoshimura N
    • Journal Title

      Plos One

      Volume: 19 Pages: 19 : e19108

    • DOI

      DOI:10.1371/journal.pone.0019108

    • Peer Reviewed
  • [Journal Article] Genetic variants in pigment epithelium-derived factor influence response of polypoidal choroidal vasculopathy to photodynamic therapy2011

    • Author(s)
      Nakata I, Yamashiro K, Yamada R, Nakanishi H, Hayashi H, Tsujikawa A, Otani A, Ooto S, Tamra H, Saito M, Saito K, Iida T, Oishi A, Kurimoto Y, Matsuda F, Yoshimura N
    • Volume
      118
    • Pages
      1408-15
    • DOI

      DOI:10.1016/j.ophtha.2010.12.011

    • Peer Reviewed
  • [Journal Article] Recovery of photoreceptor outer segments after anti-VEGF therapy for age-related macular degeneration

    • Author(s)
      Oishi A, Shimozono M, Mandai M, Hata M, Nishida A, Kurimoto Y
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 2012 in press

    • DOI

      DOI:10.1007/s00417-012-2034-4

    • Peer Reviewed
  • [Journal Article] Long-term effect of intravitreal injection of anti-VEGF agent for visual acuity and chorioretinal atrophy progression in myopic choroidal neovascularization

    • Author(s)
      Oishi A, Yamashiro K, Tsujikawa A, Ooto S, Tamura H, Nakata I, Miyake M, Yoshimura N
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

    • DOI

      DOI:10.1007/s00417-012-2022-8

    • Peer Reviewed
  • [Journal Article] Relationship between retinal morphological findings and visual function in age-related macular degeneration

    • Author(s)
      Akagi-Kurashige Y, Tsujikawa A, Oishi A, Ooto S, Yamashiro K, Tamura H, Nakata I, Ueda-Arakawa N, Yoshimura N
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

    • DOI

      DOI:10.1007/s00417-012-1928-5

    • Peer Reviewed
  • [Presentation] Retinal structure plasticity after anti-VEGF therapy for age-related macular degeneration2011

    • Author(s)
      Oishi A, Shimozono M, Mandai M, Hata M, Nishida A, Kurimoto Y
    • Organizer
      American Academy of Ophthalmology
    • Place of Presentation
      Orlando, FL
    • Year and Date
      20111022-25
  • [Presentation] The remission rate of anti-VEGF therapy for choroidal neovascularization2010

    • Author(s)
      Oishi A, Mandai M, Nishida A, Hata M, Matsuki T, Kurimoto Y
    • Organizer
      第27回日本眼循環学会(English session)
    • Place of Presentation
      神戸市
    • Year and Date
      20100730-31
  • [Book] 実践診断に役立つOCT画像撮りかた講座2011

    • Author(s)
      吉村長久監修大石明生編集
    • Publisher
      株式会社メディカ出版

URL: 

Published: 2013-07-31  

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