2012 Fiscal Year Final Research Report
Investigation of the molecular-target therapy against child cancers by using the Hedgehog signal inhibitor
| Project/Area Number |
22791708
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児腫瘍 / ヘッジホッグ / Gli1 / 横紋筋肉腫 / 分子標的治療 |
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| Research Abstract |
The mutation of Hedgehog (Hh) signal is associated with the proliferation or the carcinogenesis of several adult cancers, but little is known about child cancers. We investigated the antitumor effect of the Gli1 inhibitor Forskolin against child cancer cells, focusing on Hh signal pathway as a therapeutic target.
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