2011 Fiscal Year Final Research Report
Expression and Pathogenic Role of Cartilage Oligomeric Matrix Protein(COMP) in Keloids
| Project/Area Number |
22791720
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | 公益財団法人田附興風会 (2011)
Osaka University (2010) |
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Principal Investigator |
SHOUNO Fumie 公益財団法人田附興風会, 医学研究所第5研究部, 研究員 (30437412)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ケロイド / 同一個体 / COMP / TGF-β1 / コラーゲン / mRNA / 創傷治癒 |
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| Research Abstract |
We proved that keloid is continuously secreting COMP and Collagen out after the wound is healed. Then it was shown that the amounts of COMP secreted from keloid and from normal cells were almost the same by a simulation of early healing process using TGF-β1.Those results did not suggest that COMP itself increased Collagen production. By a transfection of COMP mRNA to both keloid cells and normal dermal cells, we found that COMP mRNA regulates collagen production. This is the first discovery of one of keloid specific biochemical regulation paths.
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