2011 Fiscal Year Final Research Report
Experimental research of the effect of nerve on negative pressure wound therapy and clinical application
| Project/Area Number |
22791743
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 創傷治癒 / 閉鎖陰圧療法 / 線維芽細胞 / 神経細胞 |
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| Research Abstract |
Kinetic change of dermal fibroblasts of rats and differentiated PC12 cells like sympathetic ganglionic neuron was investigated under various types of negative pressure. The results indicated that proliferation and migration potencies of dermal fibroblasts were promoted under intermittent negative pressure more than under atmospheric pressure, and collagen gel including dermal fibroblasts contracted under continuous negative pressure more than under atmospheric pressure. Then, the collagen gel in which dermal fibroblasts and differentiated PC12 cells were co-cultured contracted under intermittent negative pressure more than under atmospheric pressure. The results suggested that intermittent negative pressure effectively promotes wound healing.
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