2011 Fiscal Year Final Research Report
Regulatory mechanism of lipid mediator metabolism by phospholipaseA2s in influenza virus infection
| Project/Area Number |
22791744
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Akita University |
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Principal Investigator |
OHTO Takayo 秋田大学, 大学院・医学系研究科, 助教 (80511378)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 脂質生物学 / ホスホリパーゼA_2 / インフルエンザ / 脂質メタボローム |
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| Research Abstract |
The purpose of this study was to elucidate the contribution of bioactive lipid mediators to the pathogenesis of influenza virus, such as acute respiratory distress syndrome. From the results of lipid metabolome analysis, I found that some bioactive lipid molecules exhibit characteristic patterns in progression of the pathology, suggesting a possibility that these lipids alleviatethe symptoms of the infection. In addition, I propose that an influenza virus-inducible phospholipase A_2 may regulate the production of these bioactive molecules.
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