2011 Fiscal Year Final Research Report
The Development of New Therapy for Severe Left Ventricular Failure by Stem-cell Derived Chemokines
| Project/Area Number |
22791750
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 救急医学 / 集中治療医学 |
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| Research Abstract |
To determine the role of mesenchymal stem cell(MSC), bone marrow. transferred wild-type mice with ubiquitous expression ofβ-galactosidase(LacZ) in the bone marrow(BMTLacZ→Wild) were used. Intravascular injection of mesenchymal stem cell revealed MSCs can mobilize, proliferate and differenciate to cardiac tissue. Injections of the expression plasmid containing SDF-1αpromoted1) mobilization of MSC to cardiac tissue, 2) proliferation and differentiation to cardiomyocyte and 3) improvement of LV systolic function.
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