Cross-interaction induced by direct adhesion between carcinoma cell and stromal cell in oral cancer

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791765
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Osaka University
• Principal Investigator: USAMI Yu 大阪大学, 歯学部附属病院, 助教 (80444579)
• Project Period (FY): 2010 – 2011
• Keywords: 口腔病理学 / 口腔癌 / 扁平上皮癌 / 浸潤 / 転移 / 癌微小環境 / マクロファージ

Research Abstract

In this study, we evaluated the intercellular adhesion molecule-1(ICAM-1) expression in oral squamous cell carcinoma(OSCC). ICAM-1 expression was correlated with the invasiveness, lymph node metastasis, increased blood and lymphatic vessels, and macrophage infiltration. Moreover, macrophage/ OSCC-cell adhesion via ICAM-1 molecules was revealed. These findings indicate that ICAM-1 plays an important role in OSCC progression, which may result from the ICAM-1-induced the OSCC-cell activity and macrophage/ OSCC-cell adhesion.

Research Products

• [Presentation] 口腔扁平上皮癌におけるICAM-1発現は浸潤能、転移能とマクロファージの浸潤に関与する (2011)
  • Author(s): 宇佐美悠、石田健、大家香織、岸野万伸、佐藤淳、小川裕三、豊澤悟
  • Organizer: 日本歯科基礎医学会学術大会・総会
  • Place of Presentation: 岐阜県・長良川国際会議場
  • Year and Date: 2011-10-02
• [Presentation] 口腔扁平上皮癌におけるintercellular adhesion molecule 1発現は転移能と腫瘍関連炎症細胞浸潤に関与する (2011)
  • Author(s): 宇佐美悠、福田康夫、石田健、岸野万信、佐藤淳、小川裕三、豊澤悟
  • Organizer: 日本病理学会総会
  • Place of Presentation: 神奈川県・パシフィコ横浜
  • Year and Date: 2011-04-30
• [Presentation] 口腔扁平上皮癌におけるintercellular adhesion molecule 1発現は転移能と腫瘍関連炎症細胞浸潤に関与する (2010)
  • Author(s): 宇佐美悠
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 大阪府・大阪国際会議場
  • Year and Date: 2010-09-22