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2011 Fiscal Year Final Research Report

The role of anti-apoptotic Bcl-X_L in bone formation and maintenance of bone mass

Research Project

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Project/Area Number 22791771
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionNagasaki University

Principal Investigator

MORIISHI Takeshi  長崎大学, 大学院・医歯薬学総合研究科, 技術職員 (20380983)

Project Period (FY) 2010 – 2011
Keywords骨芽細胞 / アポトーシス / Bcl-XL / 骨形成
Research Abstract

In the present study, we generated transgenic mice with osteoblasts that express anti-apoptotic BCL-X_L. In BCL-X_L transgenic mice, bone volume was increased at 10 weeks of age and recognized maintenance of the bone volume at aging mice. In the recent aging society, bone volume decrease by the osteoporosis becomes the big social problem, therefore Bcl-X_L may become the target for the osteoporosis treatment in the future.

  • Research Products

    (8 results)

All 2012 2011 2010

All Journal Article (6 results) Presentation (2 results)

  • [Journal Article] OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis2012

    • Author(s)
      Mizuhashi K, Kanamoto T, Ito M, Moriishi T, Muranishi Y, Omori Y, Terada K, Komori T, Furukawa T.
    • Journal Title

      Dev Growth Differ

    • DOI

      doi:10.1111/j.

  • [Journal Article] SP7 inhibits osteoblast differentiation at a late stage in mice2012

    • Author(s)
      Yoshida CA, Komori H, Maruyama Z, Miyazaki T, Kawasaki K, Furuichi T, Fukuyama R, Mori M, Yamana K, Nakamura K, Liu W, Toyosawa S, Moriishi T, Kawaguchi H, Takada K, Komori T.
    • Journal Title

      PLoS One

      Volume: 7(3) Pages: e32364

  • [Journal Article] Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis2012

    • Author(s)
      Wang Y, Liu W, Masuyama R, Fukuyama R, Ito M, Zhang Q, Komori H, Murakami T, Moriishi T, Miyazaki T, Kitazawa R, Yoshida CA, Kawai Y, Izumi S, Komori T.
    • Journal Title

      Bone

      Volume: 50(1) Pages: 409-19

  • [Journal Article] Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis2011

    • Author(s)
      Moriishi T, Maruyama Z, Fukuyama R, Ito M, Miyazaki T, Kitaura H, Ohnishi H, Furuichi T, Kawai Y, Masuyama R, Komori H, Takada K, Kawaguchi H, Komori T.
    • Journal Title

      PLoS One

      Volume: 6(11) Pages: e27487

  • [Journal Article] Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects2011

    • Author(s)
      Maeno T, Moriishi T, Yoshida CA, Komori H, Kanatani N, Izumi S, Takaoka K, Komori T.
    • Journal Title

      Bone

      Volume: 49(4) Pages: 673-82

  • [Journal Article] Comparative morphology of the osteocyte lacunocanalicular system in various vertebrates2011

    • Author(s)
      Cao L, Moriishi T, Miyazaki T, Iimura T, Hamagaki M, Nakane A, Tamamura Y, Komori T, Yamaguchi A.
    • Journal Title

      J Bone Miner Metab

      Volume: 29(6) Pages: 662-70

  • [Presentation] 2はマウス椎間板の発達維持に必須である2011

    • Organizer
      日本分子生物学会年会プログラム・要旨集
    • Year and Date
      20110000
  • [Presentation] 骨芽細胞分化における抗アポトーシス分子Bcl-2の役割2010

    • Organizer
      第28回日本骨代謝学会学術集会学術集会プログラム抄録集
    • Year and Date
      20100000

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Published: 2013-07-31  

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