2011 Fiscal Year Final Research Report
Gene expression of Cancer Stem Cell in Oral Squamous Cell Carcinoma
| Project/Area Number |
22791777
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 口腔病理学 |
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| Research Abstract |
Cancer stem cells can be the source of all the malignant cells in a primary tumor, they can compose the small reservoir of drug-resistant cells that are responsible for relapse after a chemotherapy induced remission. In this study, we isolated oral cancer stem cell-like cells and the gene expression profile of oral cancer stem cell-like cells was examined. Our results demonstrate that the expression of keratin 34 could be a useful marker for pathologic diagnosis in terms of predicting malignant change and be a one of the makers for OSCC cancer stem cell.
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Research Products
(5 results)
